Our lab is dedicated to test and discover chemicals found in traditional remedies to prevent, slow down and even reverse the onset of protein fibril formation characteristic of Alzheimers and Parkinsons disease. We hypothesis that protein misfolding and aggregation can produce an aggregosome cascade that leads to comorbidity in other neurodegenerative disorders.
Recent Papers and Collaborations
Xiong, L., Yan, W., Zubia, E., Zhou, Y., Zhang, Y., Duan, Q., ... & Xu, G. (2018). Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12. Journal of Proteomics.
Mendez, L., Henriquez, G., Sirimulla, S., & Narayan, M. (2017). Looking Back, Looking Forward at Halogen Bonding in Drug Discovery. Molecules, 22(9), 1397.
Serrano, M., Gonzalez, V., Ray, S., Chavez, M. D., & Narayan, M. (2017). Identification of Structure-Stabilizing Interactions in Enzymes: A Novel Mechanism to Impact Enzyme Activity. Cell biochemistry and biophysics, 1-13.