Grants/Patents and Conferences
GRANTS (Recently Funded Awards) ~ 1.5 $ brought as PI and Co-PI;
Agency: NIH MBRS SCORE SC3 Title: Understanding PDI-related neurotoxicity and advancing preventative approaches
Role: PI; Amount Awarded: $453,000 (2020).
Agency: Alzheimer’s Disease Research foundation; Title: Development of curcuminoids as potent mitigators of nitrosative damage and associated neurodegenerative disorders. Purpose: To investigate efficacy of bisphenolic phytochemicals in rescuing nitrosative-stress-induced chaperone damage to PDI.
Role: PI; Duration: 03/1/2009-08/31/2014; Overlap: None
Agency: El Paso Pain Center; Title: Alzheimer’s Disease Research and Prevention
Role: PI; Duration: 09/1/2013-present
Agency: UTEP-COS; Title: Prophylactic drug development against nitrosative-stress linked Parkinson’s Role: PI; Duration: 01/1/2014-08/31/2014
Agency: NIH R21; Title: Mitigation of PCS and PTSD outcomes via biomarker identification and drug design.
Agency: NIH (R15); Title: Elucidation of NOP receptor binding mechanism and identification of lead agonists.
Role: Collaborator; Submitted and Pending Decision; Amount Requested: $250,000 (3 years)
Agency: CPRIT; Title: Prevention and Treatment of Breast Cancer with 6-desacetyl nimbinene
Role: Consultant; Submitted and Pending Decision; Amount Requested: $1,000,000
INSTITUTION: NSF UBM
Undergraduate training in Bioinformatics (September 1, 2009 - August 31, 2015).
TITLE: (Senior Personnel)
INSTITUTION: NIH/Pittsburgh Supercomputer Center (subcontract to UTEP) (Faculty Associate)
TITLE: Assisting Bioinformatics Efforts in minority schools
NIH BUILDing Scholars (Personnel participant)
TITLE: Building infrastructure leading to diversity: Southwest consortium of health-oriented education leaders and research scholars (2014-2019)
(Resource faculty for the Bioinformatics Computing Core Facility)
TITLE: Border Biomedical Research Center (BBRC)
NIH NIGMS Faculty Associate.
TITLE: Enhancement of quantitative science in biology curricula
Agency: Redsky; Title: Design and Development of PTSD-related nociceptin antagonists.
Role: PI; Duration: 03/1/2014-02/28/2015
Agency: American Heart Association; Title Target development and characterization characterization for development of next generation anti-Chagasitics; Purpose: To develop inhibitors for arresting parasite proliferation; Role: PI; Duration: 01/01/2009-12/31/2013; Overlap: None
Agency: NSF; Title: Instrumentation MRI: Acquisition of a Confocal Raman/AFM Hybrid System; Purpose: Instrument acquisition for characterization of nanoparticles and organo-inorganic materials.; Role: Co-PI; Duration: 09/01/2007-08/31/2010; Overlap: None
Agency: Academy of Applied Sciences; Title: HPLC assay development for analysis of curcuminoids and their derivatives; Purpose: To initiate Texas area High School students in to research in the Sciences; Role: PI;
Duration: 06/01/2008-08/30/2008; Overlap: None
Leung, Ming-Ying (Principal), Aley, Stephen B (Co-Principal), Kreinovich, Vladik Y (Co-Principal), Narayan, Mahesh (Co-Principal), Walsh, Elizabeth J (Co-Principal), "IGERT: Integrative Bioinformatics Training (InBiT)" Sponsored by NSF, Federal. (January 16, 2013 - January 15, 2018, $2,959,727).
Leung, Ming-Ying (Principal), Aley, Stephen B (Co-Principal), Kreinovich, Vladik Y (Co-Principal), Narayan, Mahesh (Co-Principal), Walsh, Elizabeth J (Co-Principal), "NRT-DESE: Graduate Computational Bioscience Training," Sponsored by NSF, Federal. (September 1, 2014 - August 30, 2019, $2,998,089).
RESEARCH COLLABORATORS (outside UTEP)
Ingrid Montes (UPR, Rio Piedras)
Suman Sirimulla (STLCOP, St. Lois; now at UTEP School of Pharmacy)
Creation of small molecule nociceptin (NOP)/orphanin FQ receptor agonists
Inventors: Mahesh Narayan, Suman Sirimulla, Rachid Skouta
Provisional Patent EFS ID: 21300164
INVITED TALKS (REPRESENTATIVE LIST)
251st ACS National meeting in San Diego from March 13-17, 2016 Session: Datamining: searching non-covalent interactions in chemical databases”
252nd ACS National Meeting in Philadelphia from August 21-25, 2016: Proposed session (pending LRPC approval): Medicinal Chemistry division/Halogen Bonding in Medicinal Chemistry
“Halogen Bonding Propensities in Drug: Protein Structural Interactions”, International Conference on Structural Genomics (2015) Weizmann Institute, Rehovot, Israel (Travel Award Winner)
“Phytochemical Intervention if ROS Associated Parkinson’s Pathogenesis”, (2015) University of Murcia, Murcia, Spain.
“S-Nitrosylation of Protein Disulfide Isomerase and Parkinson’s Pathogenesis: Small molecule Intervention” (2014) Department of Pharmaceutical Sciences, Suzhou University, China
“Optimizing Pharmacophore Therapeutic Indices” (2014) Institute of Nanochemistry and Nanobiology, Shanghai University, China
“Exploiting novel non-covalent interactions in lead-to-hit optimization”, (2014) Soochow University, China.
“Phytochemical Intervention in ROS Associated Parkinson’s Pathogenesis” (2014) Keynote Address to ACS Northern Arizona Chapter, Sedona, Arizona.
“Halogen bonding interactions in the PDB: Towards Rational Drug Design” International Conference on Recent advances in Structural Biology and Drug Discovery (RASBDD-IIT-2014), India. Plenary Speaker.
“Chemical Mutation of Cellular Housekeeping Machinery: Implications and Prevention” (2014) Department of Biotechnology, Jawaharlal Nehru University, Delhi, India
“In silico Design of Nociceptin Agonists for PTSD through Halogen bonding” (2014) Advancing Computational Biology @ Howard University Symposium, Washington DC
“A Tale of Two Bonds” (2014) International Symposium on Halogen Bonding (ISXB-1), Porto Cesareo, Italy.
“Neurodegenerative disorder prevention using small molecules (2014) 12th Annual Congress of International Drug Discovery Science & Technology, Suzhou, China.
“Chemical mutation of a disulfide shufflase: Implications for neurodegenerative disorders (2014) Department of Life Science, Kinki University, Osaka, Japan.
“Chemical mutation of a disulfide shufflase: Implications for neurodegenerative disorders” (2014) Department of Chemistry, School of Science, Tokai University, Kanagawa, Japan.
Chairman in National and International Conferences:
· 1st International Ayurveda Congress, September 2010, Klagenfurt, Austria
· Chair, American Chemical Society-65th Southwest Regional Meeting, Biochemistry and Cell Biology section, November 20009, El Paso, TX
· Co-Chair, Off-Shore Customized Preparation/Production for Cost-Effective Therapeutics Development BIT Life Sciences From Concept to Market Shenzhen, China April 2008
· Chair, BIT’s 4th Life Spring Forum on Protein Folding and Diseases, Shenzhen China
Recent Conference/Symposia (mostly presented by students)
James E. Becvar, Juan C. Noveron, Geoffrey Saupe, A. E. Dreyfuss, Bonnie Gunn, and Mahesh Narayan (2015) “Developing Workbooks to Financially Support PLTL Programs” Peer Led Team Learning International Society Conference, Dallas, TX, USA.
Parijat Kabiraj and Mahesh Narayan (2014) SNO-PDI mediated accumulation of LB-like inclusions in SH-SY5Y cell as a function of Aß (25-35) treatment, Gordon Research Conference, Colby College, NH, USA (Best Poster Award)
Parijat Kabiraj, Jose Marin, Armando Varela-Ramirez, Emmanuel S. Zubia, Mahesh Narayan (2014) Prevention of nitrosative stress mediated Lewy-like body formation through ellagic acid intervention in PC12 cell, 248th ACS, San Francisco, CA, USA
Sandra Andrea Salinas, Andre Perez-Orozco, Mahesh Narayan, Juan Noveron, Bonnie M. Gunn, Geoffrey Saupe, Robert Morales, and James E. Becvar (2013) “Chemistry Boot Camp” Peer Led Team Learning International Society Conference, Houston, TX, USA.
Celina Duran, Mahesh Narayan, and James E. Becvar (2013) “The Formative Assessment of Readiness (FAR) Examination” Peer Led Team Learning International Society Conference, Houston, TX, USA.
Sandra Andrea Salinas, Mason Arbogast, James E. Becvar, Geoffrey Saupe, Juan Noveron, Mahesh Narayan (2013) Peer Led Team Learning International Society Conference, Houston, TX, USA.
Jessica G. Salazar, Stephanie Moreno, Mahesh Narayan, James E. Becvar (2013) “Transmission: A Stronger Learning Modality” Peer Led Team Learning International Society Conference, Houston, TX, USA.
Ozman J. Ochoa, Bryan E. Frescas, James E. Becvar and Mahesh Narayan (2015) Objective Based Team Learning. Peer Led Team Learning International Society Conference, Dallas, TX, USA.
Zonoozi, F., Narayan, M., Becvar, J. E. (2012) Foundation of the Leaders, by the Leaders, and for the Leaders. Proceedings of the Inaugural Conference, PLTLIS, Brooklyn, NY
Becvar, J. E., Saupe, G. B., Noveron, J. C., Narayan, M. (2012) Plus Two Peer-Led Team Learning for Large Introductory STEM Classes: Improved Study Skills, Increased Retention, and Higher Graduation Rates. Proceedings of the Inaugural Conference, PLTLIS, Brooklyn, NY
Dominguez, N., Salazar, J. G., Narayan, M., Becvar, J. E. (2012) Peer Leading Helps More Than the Students Being Led. Proceedings of the Inaugural Conference. Proceedings of the Inaugural Conference, PLTLIS, Brooklyn, NY
Kalantarian, N. K., Becvar, J. E., Narayan, M., Saupe, G. B. (2012) Enhancement of public speaking paved through Peer-Led Team Learning. Proceedings of the Inaugural Conference. Proceedings of the Inaugural Conference, PLTLIS, Brooklyn, NY